Mild severity60% reported by patientsICD-10: R68.2
Summary
A persistent dryness in the mouth caused by reduced saliva production — a common side effect of medications and certain medical conditions.
What is it?
Xerostomia (dry mouth) is the subjective sensation of oral dryness, which may or may not correlate with objectively reduced salivary flow (hyposalivation). Saliva is essential for oral health — it neutralizes acids, remineralizes teeth, aids digestion, and prevents infection. Medications are the most common cause, with over 500 drugs listed as causing dry mouth including antidepressants, antihistamines, antihypertensives, and anticholinergics. Sjögren syndrome — an autoimmune condition destroying salivary glands — is the most common non-medication cause. Persistent dry mouth significantly increases dental caries and oral infection risk.
Common causes
Medications (Most Common)
Antidepressants (SSRIs, TCAs)
Antihistamines
Anticholinergics
Antihypertensives
Opioids
Diuretics
Autoimmune
Sjögren syndrome (primary or secondary)
Lupus
Rheumatoid arthritis
Medical Conditions
Diabetes mellitus
Hypothyroidism
HIV/AIDS
Anxiety / mouth breathing
Treatment-Related
Head and neck radiation therapy (damages salivary glands)
Chemotherapy
When to see a doctor
1Dry mouth persisting for more than a few weeks
2Dry mouth with dry eyes, joint pain, and fatigue (possible Sjögren syndrome)
3Rapid increase in dental cavities without dietary change
4Difficulty swallowing, speaking, or wearing dentures
5Oral pain, white patches, or sores (possible candidiasis from dry mouth)
6Dry mouth in someone who has had head and neck radiation
What you can do
✓Sip water frequently throughout the day — small amounts often rather than large gulps
✓Chew sugar-free gum or suck sugar-free candy to stimulate saliva flow
✓Use a humidifier at night to prevent mouth drying during sleep
✓Avoid alcohol-containing mouthwashes — they worsen dryness
✓Brush with fluoride toothpaste and see a dentist regularly — cavity risk is elevated
✓Limit caffeine and alcohol, which reduce salivary output
This page is for informational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always consult your doctor or a qualified health provider with questions about your symptoms or medical conditions.
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