Moderate severity48% reported by patientsICD-10: R59.9
Summary
Enlargement of lymph nodes, usually in the neck, armpits, or groin, most commonly caused by infection but occasionally a sign of lymphoma or other serious disease.
What is it?
Lymph nodes enlarge when they are actively fighting infection or infiltrated by abnormal cells. Reactive lymphadenopathy from viral or bacterial infections (strep throat, mononucleosis, dental infections) is the most common cause and typically resolves within 2–4 weeks. Generalized lymphadenopathy (multiple node groups) raises concern for systemic infection (HIV, EBV), autoimmune disease (lupus, rheumatoid arthritis), or lymphoma. Hard, fixed, non-tender, or progressively enlarging nodes in an adult without clear infectious cause require prompt evaluation.
Common causes
Infectious
Viral URIs
Mononucleosis (EBV)
Strep throat
Dental abscess
Cat scratch disease
HIV
Tuberculosis
Inflammatory / Autoimmune
Rheumatoid arthritis
Lupus
Sarcoidosis
Kikuchi disease
Malignant
Hodgkin lymphoma
Non-Hodgkin lymphoma
Leukemia
Metastatic cancer
Medications
Phenytoin
Allopurinol
Sulfonamides (drug hypersensitivity reaction)
When to see a doctor
1Lymph node that is hard, fixed, or non-tender — particularly concerning for malignancy
2Node that is rapidly growing or has been present for more than 4 weeks without explanation
3Swollen nodes accompanied by unexplained weight loss, night sweats, or persistent fever (lymphoma "B symptoms")
4Generalized swelling of multiple lymph node groups
5Swollen nodes with difficulty swallowing, breathing, or signs of abscess
What you can do
✓Most lymphadenopathy from common infections resolves on its own within 2–4 weeks
✓Warm compresses may reduce discomfort of tender cervical nodes
✓Track size, tenderness, and duration — useful information for your provider
✓Avoid squeezing or pressing on lymph nodes, especially if infected
This page is for informational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always consult your doctor or a qualified health provider with questions about your symptoms or medical conditions.
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