Swollen Lymph Nodes

Lymphadenopathy

Moderate severity48% reported by patientsICD-10: R59.9

Summary

Enlargement of lymph nodes, usually in the neck, armpits, or groin, most commonly caused by infection but occasionally a sign of lymphoma or other serious disease.

What is it?

Lymph nodes enlarge when they are actively fighting infection or infiltrated by abnormal cells. Reactive lymphadenopathy from viral or bacterial infections (strep throat, mononucleosis, dental infections) is the most common cause and typically resolves within 2–4 weeks. Generalized lymphadenopathy (multiple node groups) raises concern for systemic infection (HIV, EBV), autoimmune disease (lupus, rheumatoid arthritis), or lymphoma. Hard, fixed, non-tender, or progressively enlarging nodes in an adult without clear infectious cause require prompt evaluation.

Common causes

Infectious

  • Viral URIs
  • Mononucleosis (EBV)
  • Strep throat
  • Dental abscess
  • Cat scratch disease
  • HIV
  • Tuberculosis

Inflammatory / Autoimmune

  • Rheumatoid arthritis
  • Lupus
  • Sarcoidosis
  • Kikuchi disease

Malignant

  • Hodgkin lymphoma
  • Non-Hodgkin lymphoma
  • Leukemia
  • Metastatic cancer

Medications

  • Phenytoin
  • Allopurinol
  • Sulfonamides (drug hypersensitivity reaction)

When to see a doctor

  • 1Lymph node that is hard, fixed, or non-tender — particularly concerning for malignancy
  • 2Node that is rapidly growing or has been present for more than 4 weeks without explanation
  • 3Swollen nodes accompanied by unexplained weight loss, night sweats, or persistent fever (lymphoma "B symptoms")
  • 4Generalized swelling of multiple lymph node groups
  • 5Swollen nodes with difficulty swallowing, breathing, or signs of abscess

What you can do

  • Most lymphadenopathy from common infections resolves on its own within 2–4 weeks
  • Warm compresses may reduce discomfort of tender cervical nodes
  • Track size, tenderness, and duration — useful information for your provider
  • Avoid squeezing or pressing on lymph nodes, especially if infected

Conditions that cause this symptom

Medications that may help

Treatment depends on the underlying cause. Always consult your provider before starting any medication.

Frequently asked questions

This page is for informational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always consult your doctor or a qualified health provider with questions about your symptoms or medical conditions.

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